This video describes how to use the partial differences strategy to solve multi-digit subtraction. The partial differences strategy eliminates the need to regroup numbers. The partial differences strategy is typically performed left to right and focuses on subtracting only part of each multi-digit number at a time (e.g., only subtracting digits in the hundreds column to determine the partial difference of hundreds). It may be important for students to know and understand the partial differences strategies if they have not yet developed the understanding for regrouping that is necessary to use the standard algorithm; however, this strategy does introduce some complexities. Students may encounter situations where they need to use negative integers because they may be moving from the positive side of the number line to the negative side of the number line when determining differences.